Garcinia Cambogia: Weight- Loss Supplement May Be Toxic to Some. By Agata Blaszczak- Boxe, Staff Writer Published: 0. AM EDT on Live. Science The use of Garcinia cambogia, a popular weight- loss supplement, may pose health risks to people who are taking certain antidepressants, a recent case report suggests. Last year in Oregon, a 3. Garcinia cambogia supplements for two or three months while also taking an antidepressant started stuttering and sweating profusely. In the emergency room of a local hospital, the medical staff noted that the woman's heart rate and blood pressure were high, and that she had also developed foot clonus, involuntary muscle spasms that cause a person's foot to flex. The woman's symptoms were characteristic of serotonin toxicity, a drug reaction that occurs when levels of the neurotransmitter serotonin are too high. After the woman was given medication for serotonin toxicity and spent a few days at the hospital, her symptoms subsided and she eventually recovered. Robert Hendrickson, one of the authors of the case report. However, previous studies on people and animals have shown that Garcinia cambogia may, indeed, increase serotonin levels. And taking the supplement in combination with antidepressants known as selective serotonin reuptake inhibitors (SSRIs), which also cause serotonin levels to rise, could lead to serotonin toxicity, said Hendrickson, a toxicologist at the Department of Emergency Medicine of Oregon Health and Sciences University. Hendrickson added that, based on the animal and human data suggesting both SSRIs and Garcinia increase serotonin levels, he recommends that people who are taking an SSRI not use Garcinia, at least until further research is done. However, researchers have so far found only mixed results when looking at whether the supplement really helps weight loss. And one study in rats suggested that extremely high doses of Garcinia may cause testicular atrophy, and toxicity. ![]() Parents Forced to Say Goodbye to Terminally Ill 10-Month-Old Baby as Courts Decide to Take Him Off Life Support. The fact is I maybe saw him 5 days. Sonyia Says: 12-05-07 at 10:27. Dunham, one of Hillary Clinton’s most committed celebrity surrogates during the campaign, said her friends were asking what she was doing to lose the weight. Qnexa is a new, potent, effective and safe weight-loss drug that will help in the fight against obesity; it is poised to become the first FDA-approved weight-loss. Detoxes are popular, but does your body really need help cleansing itself? Find out how detox diets work and what the science says. It’s true — decreased appetite and weight loss are possible side effects of Adderall use. Both adults and children can have these effects while using this drug. The woman in the case report had been previously diagnosed with serotonin toxicity while she was taking a different kind of antidepressant. At that time, she had also been taking Garcinia for a month or two, but she didn't tell the doctor who prescribed her antidepressant that she had also been taking the weight- loss supplement, Hendrickson said. Therefore, her doctor attributed her first case of serotonin toxicity to her first antidepressant, and switched her to another one. Then, she developed her second case of toxicity, for which Hendrickson saw her. Admit it -- everyone's looking for a quick and easy way to lose weight. Fad diets seduce us with fast, “drastic” results, but they’re. How to Lose Weight Like a Model. Looking at models and celebrities may have you wondering what type of diet or exercise program they're following to keep their thin. 17 most extreme celebrity weight loss and gains, as Bradley Cooper piles on 40lbs for Hollywood movie We look at the most shocking and dramatic body transformations. Another potential, but less likely, trigger of the reaction, could have been the SSRI that she had been taking. Moreover, it is also possible that although the supplement she was taking was labeled as Garcinia, it might not have contained the supplement, but rather some other substance, Hendrickson said. Medications are highly regulated. Whereas people can be relatively certain that a bottle of medication contains the ingredients that it is supposed to contain, the same cannot be said about supplements. Previous research has shown that some supplements did not contain the herbs or other substances that their bottles said they contained. Moreover, there have also been instances in which other substances sold as supplements contained pharmaceutical agents, Hendrickson said. For instance, valerian root supplement pills that are sold as an herbal sleep aid have been found to contain valium, as it was cheaper for the pill manufacturer to use the drug than the herb, he said. However, most capsules labeled Garcinia likely do include Garcinia, Hendrickson said. And because previous studies have shown that Garcinia causes a serotonin increase, it is quite likely that this also occurred in the case discussed in the study, the researchers said. The study was published online April 4 in the Journal of Medical Toxicology. Follow Agata Blaszczak- Boxe on Twitter. Follow. Live Science @livescience, Facebook& Google+. Original article on Live Science. Copyright 2. 01. 4 Live. Science, a Tech. Media. Network company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed. Sculptor. Body TM. 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